Mitochondrial & Metabolic

NAD+ / Nicotinamide Adenine Dinucleotide

Essential coenzyme for cellular energy metabolism and DNA repair. Utilized for mitochondrial support, PARP activation, and sirtuin optimization in functional medicine protocols.

MECHANISM
Mitochondrial ETC Support
TARGET
Sirtuin Activation
HALF-LIFE
Short (Rapid Uptake)
⚠

For Professional Reference Only: Off-label use. Not FDA approved for anti-aging. Verify all dosing individually. Due to the potential for side effects (flushing, nausea, palpitations) caused by rapid infusion or high initial doses, a "Low and Slow" titration protocol is universally recommended.

Select Protocol Intensity

STANDARD

Injection (SubQ)

Bioavailability: ~100%
Starting Dose 25 mg
Target Dose 100 mg
Frequency 3x / Week
*Administer SubQ into abdominal fat. Rotate sites.

Oral / Liposomal

Bioavailability: Variable
Daily Dose 300 mg
Timing Morning (Fasted)
Support TMG (Methylation)
*Often combined with Resveratrol or Quercetin.

Titration Schedule Visualization

Recommended ramp-up schedule to mitigate side effects (flushing, abdominal discomfort). This chart updates based on the selected protocol above.

Treatment Duration & Cycling

Continuous use may downregulate endogenous production. Cycling is recommended.

ON: 6-12 Weeks
OFF: 2-4 Weeks

Clinical Notes:

  • Washout: 2-4 weeks usually sufficient to reset receptors.
  • Maintenance: Once target tissue levels reached, frequency can often drop to 1-2x/week maintenance inj.
  • Side Effects: If nausea occurs, reduce dose by 25% and hold for 1 week.

Vial Longevity Calculator

Estimate prescription duration based on concentration and dose.

25mg 50 mg 250mg

Total Doses per Vial

40

At 3x/week = 13.3 weeks supply

Contraindications & Cautions

Active Cancer: Theoretical risk of fueling tumor growth via PARP pathways. Avoid in active oncological cases.

Methylation Status: NAD+ metabolism consumes methyl groups. Consider co-prescribing TMG (Trimethylglycine).

Pregnancy/Lactation: Insufficient safety data.